The ARIA Breast Imaging System has demonstrated superiority over the combined use of mammography and conventional ultrasound at detecting solid masses, an ability to image dense breast tissue effectively, regardless of age or ethnicity, with results that correlate well to actual pathology and superior needle definition provides greater accuracy for image-guided biopsy. Other system features include 3D rendering and lesion segmentation with contrast attenuation comparison, retrieval of prior comparative studies for quick cross-correlation with known landmarks for year to year comparison, and seamless integration into the patient workflow. Minimal operator dependence, due to automated scan capabilities, contributes to improved workflow efficiencies.