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DISCLOSURES |
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C.W.
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- Nothing to disclose.
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T.A.
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- Nothing to disclose.
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G.M.
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- Research support, Siemens AG
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E.d.
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- Nothing to disclose.
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K.R.
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- Nothing to disclose.
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J.M.
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- Nothing to disclose.
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.e.
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| | PURPOSE |
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To determine whether the effects of secondhand cigarette smoke in the lungs can be detected using long-time-scale (LTS) global hyperpolarized 3He (GH3He) diffusion MRI.
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| | METHOD AND MATERIALS |
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LTS GH3He diffusion MRI was performed in 38 subjects: 33 healthy subjects who never smoked (17 subjects with low exposure to secondhand smoke: 7 M, 10 F, age: 46-73 yrs; and 16 with high exposure: 4 M, 12 F, age: 41-79 yrs) and 5 active smokers (3 M, 2 F, age: 48-71 yrs, FEV1%pred: 58%-92%) using a 1.5T scanner (Sonata, Siemens). In all subjects, global LTS ADC values were obtained after inhalation of 50 ml of H3He mixed with 950 ml of N2. ADC values were calculated at multiple diffusion times (20ms ~ 2.5s, interval: 62ms), however for the sake of brevity only the ADC values at a diffusion time of 1.54s are presented below.
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| | RESULTS |
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Global ADC values for smoking subjects (mean±SD: 0.0327±0.0086 cm2/s) were significantly greater than those for low exposure healthy subjects (0.0184±0.0033 cm2/s), p=0.02. ADC values for subjects with high exposure (0.0201±0.0068 cm2/s) were more variable than those of low exposure subjects but mean values were similar, p=0.38. Five (31%) high exposure subjects, but only 1 (6%) with low exposure had ADC values greater than 0.0230 cm2/s; 1 (6%) high exposure subject, but 9 (53%) with low exposure had ADC values between 0.0185 cm2/s and 0.0230 cm2/s; and 10 (63%) high exposure subjects, but 7 (41%) with low exposure had ADC values less than 0.0185 cm2/s, p<0.01. Thus, the high exposure group tended toward ADC values that were either higher or lower than the low exposure group.
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| | CONCLUSION |
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Only a fraction (15-30%) of active smokers develop emphysema (structural damage to the lung) while a larger fraction develop chronic bronchitis (chronic airway inflammation). A decrease in ADC values may reflect airway narrowing possibly from early chronic bronchitis, and an increase may be indicative of structural lung damage/sub-clinical emphysema. Our findings suggest that the effects of secondhand smoke in the lungs can be detected using LTS GH3He diffusion MRI.
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| | CLINICAL RELEVANCE/APPLICATION |
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The effects of secondhand smoke in the lungs can be detected using long-time-scale global hyperpolarized He3 diffusion MRI.
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QUESTIONS ABOUT THIS EVENT EMAIL: |
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wangc@email.chop.edu |
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